Ontology highlight
ABSTRACT:
SUBMITTER: Zhou B
PROVIDER: S-EPMC9088529 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Zhou Bing B Song Shuo S Guo Huimin H Zhou Xinrong X Fan Qing Q Liu Weilong W Cheng Lin L Ge Xiangyang X Ju Bin B Zhang Zheng Z
Journal of medical virology 20220506 8
The SARS-CoV-2 vaccines have been widely used to build an immunologic barrier in the population against the COVID-19 pandemic. However, a newly emerging Omicron variant, including BA.1, BA.1.1, BA.2, and BA.3 sublineages, largely escaped the neutralization of existing neutralizing antibodies (nAbs), even those elicited by three doses of vaccines. Here, we used the Omicron BA.1 RBD as a fourth dose of vaccine to induce potent Omicron-specific nAbs and evaluated the broadly neutralizing activities ...[more]