Ultrasonic Irradiation Enables Facile Production of Lovastatin from Sugar Cane Bagasse.

ABSTRACT: This study investigated the effect of ultrasound-assisted hydrogen peroxide (H₂O₂) pretreatment on sugar cane bagasse (SCB) followed by Monascus purpureus TISTR 3003 cultivation for lovastatin production under solid-state fermentation (SSF). Optimization of the pretreatment conditions was investigated using a response surface methodology (RSM). Within the range of the selected operating conditions, the optimized values of H₂O₂ concentration, amplitude, SCB dosage, and sonication time were found to be 2.74%, 83.22 μm, 2.84% and 52.29 min, respectively. The R ² value of 0.9749 indicated that the fitted model is in good agreement with the predicted and actual lovastatin production. On the basis of the optimum conditions, the

SUBMITTER: Rugthaworn P 

PROVIDER: S-EPMC9088786 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature