Sex Differences in the Association of Pretransfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant.

ABSTRACT:

Objective

To assess sex-specific differences in early brain structure and function of preterm infants after red blood cell (RBC) transfusions.

Study design

A single-center subset of infants with a birth weight <1000 g and gestational age 22-29 weeks were enrolled from the National Institute of Child Health and Human Development's Neonatal Research Network Transfusion of Prematures Trial. Hemoglobin (Hb) concentration obtained directly before each transfusion (pretransfusion Hb [ptHb]) was obtained longitudinally throughout each infant's neonatal intensive care unit stay and used as a marker of degree of anemia (n = 97). Measures of regional brain volumes using magnetic resonance imaging were obtained at ∼40 weeks postmenstrual age or at hospital discharge, if earlier (n = 29

SUBMITTER: Benavides A 

PROVIDER: S-EPMC9088851 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature