Morphology-dependent pH-responsive release of hydrophilic payloads using biodegradable nanocarriers.

ABSTRACT: The development of functional nanocarriers with stimuli-responsive properties has advanced tremendously to serve biomedical applications such as drug delivery and regenerative medicine. However, the development of biodegradable nanocarriers that can be loaded with hydrophilic compounds and ensure its controlled release in response to changes in the surrounding environment still remains very challenging. Herein, we achieved such demands via the preparation of aqueous core nanocapsules using a base-catalyzed interfacial reaction employing a diisocyanate monomer and functional monomers/polymers containing thiol and hydroxyl functionalities at the droplet interface. pH-responsive poly(thiourethane-urethane) nanocarriers with ester linkages were synthesized by incorporating polycaprolact

SUBMITTER: Pramanik SK 

PROVIDER: S-EPMC9088891 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature