Quenching the Macroporous Collapse of Polyelectrolyte Multilayer Films for Repeated Drug Loading.

ABSTRACT: Macroporous structures can be developed within polyelectrolyte multilayer films for efficient drug loading, but these structures tend to collapse or fracture during conventional drying procedures. Herein, a facile dehydrating method for macroporous polyelectrolyte multilayer films is proposed using solvent exchange to ethanol and then spontaneous evaporation. During these processes, the collapse of the macroporous structures can be effectively avoided, which can be ascribed to a combined effect of two factors. On one hand, capillary pressure during ethanol evaporation is relatively small since the surface tension of ethanol is much lower than that of water. On the other hand, solvent exchange suppresses the interdiffusion of polyelectrolytes and substantially increases the mechanical stren

SUBMITTER: Liang ZX 

PROVIDER: S-EPMC9088898 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature