Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults.

ABSTRACT:

Background

Poor vascular health may impede brain functioning in older adults, thus possibly increasing the risk of cognitive decline and Alzheimer's disease (AD). The emerging link between vascular risk factors (VRF) and longitudinal decline in resting-state functional connectivity (RSFC) within functional brain networks needs replication and further research in independent cohorts.

Method

We examined 95 non-demented older adults using the IMAP+ cohort (Caen, France). VRF were assessed at baseline through systolic and diastolic blood pressure, body-mass-index, and glycated hemoglobin (HbA1c) levels. Brain pathological burden was measured using white matter hyperintensity (WMH) volumes, derived from FLAIR images, and cortical β-Amyloid (Aβ) deposition, derived from florbetapi

SUBMITTER: Wirth M 

PROVIDER: S-EPMC9088922 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature