Assessment of the Toxicity of Aluminum Oxide and Its Nanoparticles in the Bone Marrow and Liver of Male Mice: Ameliorative Efficacy of Curcumin Nanoparticles.

ABSTRACT: The potential influence of nanoparticles (NPs) on the liver and bone marrow has received attention. The aim of this work was to evaluate the effect of nanocurcumin on the oxidative stress, apoptosis, and toxicity induced by Al₂O₃ and its NPs. The experimental animals (n = 72 mice) were divided into the following groups: group I, as a control; groups II and III, as aluminum oxide and its NPs (6 mg/kg); group IV, as aluminum oxide + nanocurcumin (Al₂O₃ + N-Cur, 20 mg/kg); and group V, as aluminum oxide NPs + nanocurcumin (Al₂O₃-NP + N.Cur., 20 mg/kg). Al₂O₃ and its NP groups significantly increased p53, Nrf2 levels, and the white blood cell count. They also decreased the Hsp70 level, antitrypsin, i

SUBMITTER: Alghriany AAI 

PROVIDER: S-EPMC9088947 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature