Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM_2.5 )-induced cardiac dysfunction via ACE2 signalling.

ABSTRACT: Air pollution, via ambient PM_2.5, is a big threat to public health since it associates with increased hospitalisation, incidence rate and  mortality of cardiopulmonary injury. However, the potential mediators of pulmonary injury in PM_2.5 -induced cardiovascular disorder are not fully understood. To investigate a potential cross talk between lung and heart upon PM_2.5 exposure, intratracheal instillation in vivo, organ culture ex vivo and human bronchial epithelial cells (Beas-2B) culture in vitro experiments were performed respectively. The exposed supernatants of Beas-2B were collected to treat primary neonatal rat cardiomyocytes (NRCMs). Upon intratracheal instillation, subacute PM_2.5 exposure caused cardiac dysfunction, which was time-dependent

SUBMITTER: Wang H 

PROVIDER: S-EPMC9089227 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature