Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer.

ABSTRACT: Chemo-photothermal therapy, which exhibits synergistic effects, is more effective than either of the treatments administered alone because of its superior ability to target and destroy cancer cells. An anti-cancer compound (doxorubicin, DOX) was embedded in silica-carbon hollow spheres (SCHSs) using heat and vacuum to integrate multi-therapeutic effects onto one platform and subsequently improve the anti-cancer efficacy. SCHSs were synthesized via a surface activation method and its highly porous surface enhanced the loading content of the desired drug. SCHSs are an infrared photothermal material that can destroy targeted cells by heating under near-infrared (NIR) laser illumination at 808 nm. NIR laser illumination also enhances DOX release from SCHSs to increase the anti-cancer ef

SUBMITTER: Chen YC 

PROVIDER: S-EPMC9089277 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature