Biocompatible zwitterionic copolymer-stabilized magnetite nanoparticles: a simple one-pot synthesis, antifouling properties and biomagnetic separation.

ABSTRACT: A simple one-pot synthesis of biocompatible and antifouling magnetite nanoparticles (Fe₃O₄NPs) was developed. The process involves co-precipitation and in situ coating of zwitterionic copolymer poly[(methacrylic acid)-co-(2-methacryloyloxyethyl phosphorylcholine)] (PMAMPC). The influence of one-step and two-step coating methods on the performance of modified Fe₃O₄NP was investigated. The PMAMPC-Fe₃O₄NP with a narrow particle size distribution obtained from the two-step approach were highly stable in aqueous media within a wide range of pH. The particles exhibited superparamagnetic behavior with high saturation magnetization values so that they could be easily separated from solution by a magnet. Their antifouli

SUBMITTER: Boonjamnian S 

PROVIDER: S-EPMC9089288 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature