Enzymatic synthesis and self-assembly of glycolipids: robust self-healing and wound closure performance of assembled soft materials.

ABSTRACT: In developing countries, wounds are a major health concern and pose a significant problem. Hence, the development of new materials that can act as scaffolds for in situ tissue regeneration and regrowth is necessary. In this report, we present a new class of injectable oleogel and composite gel derived from glycolipids that provide reversible interlinked 3D fiberous network architecture for effective wound closure by tissue regrowth and regeneration. Glycolipids were derived from α-chloralose and various vinyl esters using Novozyme 435, an immobilized lipase B from Candida antarctica as a catalyst, in good yield. These glycolipids undergo spontaneous self-assembly in paraffin oil to form an oleogel, in which curcumin was successfully incorporated to generate a composite gel. M

SUBMITTER: Prasad YS 

PROVIDER: S-EPMC9089313 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature