PH-responsive and porous vancomycin-loaded PLGA microspheres: evidence of controlled and sustained release for localized inflammation inhibition in vitro.

ABSTRACT: Adequate delivery of antibiotics to infected sites is crucial for the effective treatment of bacterial infections. A controlled and sustained release system based on porous and pH-responsive poly(lactic-co-glycolic acid) (PLGA)-vancomycin (Van) microspheres was developed. In this system, drug release is triggered by the weakly acidic environment, like local inflamed tissues. The microspheres, developed through the W₁/O/W₂ double-emulsion evaporation method, comprised a PLGA-based shell and a core containing Van and the bubble-generating agent of NaHCO₃. The optimized preparation conditions for PLGA-NaHCO₃-Van microspheres were investigated and characterized. The PLGA-NaHCO₃-Van microspheres exhibited porous microstructures with

SUBMITTER: Yu X 

PROVIDER: S-EPMC9089331 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature