Cytochrome P450-dependent reactive oxygen species (ROS) production contributes to Mn₃O₄ nanoparticle-caused liver injury.

ABSTRACT: Mn₃O₄ nanoparticles (NPs) are one of the most important nanomaterials, and have a wide range of applications (i.e., catalysis, solar-electron transformation and molecular adsorption). However, their biological effect remains to be detailed. In this study, we investigated the in vivo toxicity of the synthesized Mn₃O₄ NPs using a long-term exposure model. After exposure to the Mn₃O₄ NPs for 60-120 days, rats preferentially accumulated manganese in the livers. Histopathological observation and apoptosis assays revealed that the Mn₃O₄ NPs caused severe liver injury associated with apoptosis. Transcription profiling analysis, immune histochemistry (IHC) staining and western blotting showed that

SUBMITTER: Yue Z 

PROVIDER: S-EPMC9089396 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature