UCN-SiO₂-GO: a core shell and conjugate system for controlling delivery of doxorubicin by 980 nm NIR pulse.

ABSTRACT: Herein, graphene oxide (GO) has been attached with core-shell upconversion-silica (UCN-SiO₂) nanoparticles (NPs) to form a GO-UCN-SiO₂ hybrid nanocomposite and used for controlled drug delivery. The formation of the nanocomposite has been confirmed by various characterization techniques. To date, a number of reports are available on GO and its drug delivery applications, however, the synergic properties that arise due to the combination of GO, UCNPs and SiO₂ can be used for controlled drug delivery. New composite UCN@SiO₂-GO has been synthesized through a bio-conjugation approach and used for drug delivery applications to counter the lack of quantum efficiency of the upconversion process and control sustained release. A model anticancer drug (dox

SUBMITTER: Paik P 

PROVIDER: S-EPMC9089400 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature