One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy.

ABSTRACT: Nanomaterials have been widely used as drug carriers in the biomedical field. However, most of them have limited application because of their poor biocompatibility, targeting, and degradability. Therefore, exploring and developing novel drug nanocarriers to overcome these problems has widely attracted attention. In this study, polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot oil-water biphase stratification approach. PMSNs showed good biodegradability in degradation experiments and also proved to have superior biocompatibility toward hepatocellular carcinoma cells (HepG2) compared with mesoporous silica nanoparticles (MSNs). And PMSNs loaded doxorubicin (DOX) (PMSNs@DOX) exhibited a pH-responsive release effect. Meanwhile, compared with

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9089436 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature