An AC electrothermal self-circulating system with a minimalist process to construct a biomimetic liver lobule model for drug testing.

ABSTRACT: Liver-on-chip, due to its precision and low cost for constructing in vitro models, has tremendous potential for drug toxicity testing and pathological studies. By applying APAP (acetaminophen) treatment of different concentrations, a dynamic self-circulating liver lobule model for drug testing was proven useful for emulating the human physiological system. However, the demand for a dynamic system of on-chip organs is difficult to fulfil due to the relatively cumbersome fabrication processes. In this paper, the design and fabrication of an AC electrothermal self-circulating system combined with a 3D biomimetic liver lobule is described. The system was fabricated using a low-cost ITO laser etching process within a few seconds. A large number of interdigital electrodes were arranged in

SUBMITTER: Mi S 

PROVIDER: S-EPMC9089443 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature