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Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles.


ABSTRACT: A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope.

SUBMITTER: Aksenov NA 

PROVIDER: S-EPMC9089741 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles.

Aksenov Nicolai A NA   Aksenov Alexander V AV   Prityko Lidiya A LA   Aksenov Dmitrii A DA   Aksenova Daria S DS   Nobi Mezvah A MA   Rubin Michael M  

ACS omega 20220415 16


A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope. ...[more]

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