Photoinduced Trifluoromethylation with CF₃Br as a Trifluoromethyl Source: Synthesis of α-CF₃-Substituted Ketones.

ABSTRACT: An efficient and novel photoinduced trifluoromethylation employing CF₃Br as a trifluoromethyl source is described. With commercially accessible fac-Ir^(III)(ppy)₃ as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF₃Br occurs successfully. This method provides various α-CF₃-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.

SUBMITTER: Ma R 

PROVIDER: S-EPMC9089747 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature