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Photoinduced Trifluoromethylation with CF₃Br as a Trifluoromethyl Source: Synthesis of α-CF₃-Substituted Ketones.

ABSTRACT: An efficient and novel photoinduced trifluoromethylation employing CF₃Br as a trifluoromethyl source is described. With commercially accessible fac-Ir^(III)(ppy)₃ as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF₃Br occurs successfully. This method provides various α-CF₃-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.

SUBMITTER: Ma R

PROVIDER: S-EPMC9089747 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Photoinduced Trifluoromethylation with CF3Br as a Trifluoromethyl Source: Synthesis of α-CF3-Substituted Ketones.

Ma Ransong R Deng Zhoubin Z Wang Ke-Hu KH Wang Junjiao J Huang Danfeng D Su Yingpeng Y Hu Yulai Y Lv Xiaobo X

ACS omega 20220412 16

An efficient and novel photoinduced trifluoromethylation employing CF3Br as a trifluoromethyl source is described. With commercially accessible fac-Ir(III)(ppy)3 as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF3Br occurs successfully. This method provides various α-CF3-substituted ketones with a broad substrate scope in good yields under mild reaction conditions. ...[more]

PMID: 35573213

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