Single-cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney.

ABSTRACT: Cutaneous lupus is commonly present in patients with systemic lupus erythematosus (SLE). T cells have been strongly suspected to contribute to the pathology of cutaneous lupus; however, our understanding of the relevant T cell phenotypes and functions remains incomplete. Here, we present a detailed single-cell RNA-Seq profile of T and NK cell populations present within lesional and nonlesional skin biopsies of patients with cutaneous lupus. T cells across clusters from lesional and nonlesional skin biopsies expressed elevated levels of IFN-simulated genes (ISGs). Compared with T cells from control skin, however, T cells from cutaneous lupus lesions did not show elevated expression profiles of activation, cytotoxicity, or exhaustion. Integrated analyses indicated that skin lymphocytes appea

SUBMITTER: Dunlap GS 

PROVIDER: S-EPMC9089784 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature