Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons.

ABSTRACT: The transformation of synaptic input into action potential output is a fundamental single-cell computation resulting from the complex interaction of distinct cellular morphology and the unique expression profile of ion channels that define the cellular phenotype. Experimental studies aimed at uncovering the mechanisms of the transfer function have led to important insights, yet are limited in scope by technical feasibility, making biophysical simulations an attractive complementary approach to push the boundaries in our understanding of cellular computation. Here we take a data-driven approach by utilizing high-resolution morphological reconstructions and patch-clamp electrophysiology data together with a multi-objective optimization algorithm to build two populations of biophysically deta

SUBMITTER: Linaro D 

PROVIDER: S-EPMC9089861 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature