Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia.

ABSTRACT: Ischemic stroke is the leading cause of death and disability worldwide, and restoring the blood flow to ischemic brain tissues is currently the main therapeutic strategy. However, reperfusion after brain ischemia leads to excessive reactive oxygen species production, inflammatory cell recruitment, the release of inflammatory mediators, cell death, mitochondrial dysfunction, endoplasmic reticulum stress, and blood-brain barrier damage; these pathological mechanisms will further aggravate brain tissue injury, ultimately affecting the recovery of neurological functions. It has attracted the attention of researchers to develop drugs with multitarget intervention effects for individuals with cerebral ischemia. A large number of studies have established that curcumin plays a significant neuropro

SUBMITTER: Fan F 

PROVIDER: S-EPMC9090137 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature