Ontology highlight
ABSTRACT:
SUBMITTER: Vichaikul S
PROVIDER: S-EPMC9090238 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Vichaikul Sirapa S Gurrea-Rubio Mikel M Amin M Asif MA Campbell Phillip L PL Wu Qi Q Mattichak Megan N MN Brodie William D WD Palisoc Pamela J PJ Ali Mustafa M Muraoka Sei S Ruth Jeffrey H JH Model Ellen N EN Rohraff Dallas M DM Hervoso Jonatan L JL Mao-Draayer Yang Y Fox David A DA Khanna Dinesh D Sawalha Amr H AH Tsou Pei-Suen PS
JCI insight 20220509 9
Binding of the bromodomain and extraterminal domain proteins (BETs) to acetylated histone residues is critical for gene transcription. We sought to determine the antifibrotic efficacy and potential mechanisms of BET inhibition in systemic sclerosis (SSc). Blockade of BETs was done using a pan-BET inhibitor, JQ1; BRD2 inhibitor, BIC1; or BRD4 inhibitors AZD5153 or ARV825. BET inhibition, specifically BRD4 blockade, showed antifibrotic effects in an animal model of SSc and in patient-derived diffu ...[more]