Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19.

ABSTRACT: Severe COVID-19 disease is associated with dysregulation of the myeloid compartment during acute infection. Survivors frequently experience long-lasting sequelae, but little is known about the eventual persistence of this immune alteration. Herein, we evaluated TLR-induced cytokine responses in a cohort of mild to critical patients during acute or convalescent phases (n = 97). In the acute phase, we observed impaired cytokine production by monocytes in the patients with the most severe COVID-19. This capacity was globally restored in convalescent patients. However, we observed increased responsiveness to TLR1/2 ligation in patients who recovered from severe disease, indicating that these cells display distinct functional properties at the different stages of the disease. In patients with a

SUBMITTER: Brauns E 

PROVIDER: S-EPMC9090263 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature