Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota.

ABSTRACT: The neonatal intestinal tract is immature and can be easily infected by pathogens causing inflammation. Maternal diet manipulation is a promising nutritional strategy to enhance the gut health of offspring. A fermented diet is a gut microbiota targeting diet containing live probiotics and their metabolites, which benefit the gut and overall health host. However, it remains unclear how a maternal fermented diet (MFD) affects neonatal intestinal inflammation. Here, in vivo and in vitro models together with multi-omics analysis were applied to investigate the impacts and the underlying mechanism through which an MFD prevents from gut inflammation in neonates. An MFD remarkably improved the performance of both sows and piglets and significantly altered the gut microbiome and milk

SUBMITTER: Wang C 

PROVIDER: S-EPMC9090288 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature