Synthesis and fluorescent properties of boroisoquinolines, a new family of fluorophores.

ABSTRACT: First representatives of a new family of isoquinolines, so called boroisoquinolines, were synthesized and characterized. The synthesis was based on the insertion of the difluoroboranyl group into the 1-methylidene-3,4-dihydroisoquinoline core. The optimization of the 2-difluoroboranyl-3,4-dihydroisoquinoline-1(2H)-ylidene core led to efficient fluorescence in a range of 400-600 nm with outstanding (>100 nm) Stokes shifts. The compounds might be suitable for reversible or irreversible labelling of proteins, particularly the cannabinoid receptor CB₂.

SUBMITTER: Sovari D 

PROVIDER: S-EPMC9090577 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature