Patient perspectives on window of opportunity clinical trials in early-stage breast cancer.

ABSTRACT:

Purpose

Window of opportunity trials (WOT) are increasingly common in oncology research. In WOT participants receive a drug between diagnosis and anti-cancer treatment, usually for the purpose of investigating that drugs effect on cancer biology. This qualitative study aimed to understand patient perspectives on WOT.

Methods

We recruited adults diagnosed with early-stage breast cancer awaiting definitive therapy at a single-academic medical center to participate in semi-structured interviews. Thematic and content analyses were performed to identify attitudes and factors that would influence decisions about WOT participation.

Results

We interviewed 25 women diagnosed with early-stage breast cancer. The most common positive attitudes toward trial participation were a de

SUBMITTER: Parikh DA 

PROVIDER: S-EPMC9090598 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature