Selective enrichment of sialylated glycopeptides with a d-allose@SiO₂ matrix.

ABSTRACT: Abnormal sialylation of glycoprotein is associated with different kinds of cancers and neurodegenerative diseases. However, analysis of low abundance sialylated glycopeptides (SGPs) from complex biological samples is still a big challenge. To solve the problem, materials with high SGPs enrichment selectivity should be designed and prepared. Inspired by the saccharide-saccharide interaction in life systems, a d-allose@SiO₂ (ABS) material was prepared and applied in SGPs enrichment under hydrophilic interaction liquid chromatography (HILIC) mode. Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), and nitrogen adsorption experiment results proved that the ABS matrix was successfully synthesized. The SGPs enrichment selectivity of ABS matrix was eval

SUBMITTER: Sun N 

PROVIDER: S-EPMC9090606 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature