Aza-BODIPY based polymeric nanoparticles for cancer cell imaging.

ABSTRACT: Near infrared (NIR) fluorescent dyes that are widely used for cancer imaging usually suffer from their hydrophobicity. To overcome this problem, a water-suspendable and biodegradable NIR-light-activating aza-BODIPY (AZB-NO₂) encapsulated in polymeric nanoparticles was prepared as a new class of deep-tissue imaging agent. AZB-NO₂ possesses an intense, broad NIR absorption band (600-800 nm) with a remarkably high fluorescent quantum yield. After being encapsulated with a biodegradable polycaprolactone (PCL) and a Kolliphor P188 surfactant by emulsification-solvent evaporation method, the AZB-NO₂ formed a spherical shape as observed in scanning electron micrographs (SEM) with a hydrodynamic average size of 201 nm (average PDI = 0.185). The results from transmi

SUBMITTER: Chansaenpak K 

PROVIDER: S-EPMC9090774 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature