CXCL9 inhibits tumour growth and drives anti-PD-L1 therapy in ovarian cancer.

ABSTRACT:

Background

Response to immune checkpoint blockade (ICB) in ovarian cancer remains disappointing. Several studies have identified the chemokine CXCL9 as a robust prognosticator of improved survival in ovarian cancer and a characteristic of the immunoreactive subtype, which predicts ICB response. However, the function of CXCL9 in ovarian cancer has been poorly studied.

Methods

Impact of Cxcl9 overexpression in the murine ID8-Trp53^-/- and ID8-Trp53^-/-Brca2^-/- ovarian cancer models on survival, cellular immune composition, PD-L1 expression and anti-PD-L1 therapy. CXCL9 expression analysis in ovarian cancer subtypes and correlation to reported ICB response.

Results

CXCL9 overexpression resulted in T-cell accumulation, delayed ascites format

SUBMITTER: Seitz S 

PROVIDER: S-EPMC9090786 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature