Early life Lactobacillus rhamnosus GG colonisation inhibits intestinal tumour formation.

ABSTRACT:

Background

Gut microbiota dysbiosis is closely related to the progression of colorectal cancer. Our previous study revealed that early life colonisation with Lactobacillus rhamnosus GG (LGG) had long-term positive effects on health. We sought to investigate whether early life LGG colonisation could inhibit intestinal tumour formation in offspring.

Methods

Adult C57BL/6 female mice were mated with Apc^min/+ male mice. Pregnant mice with the same conception date received 10⁸ cfu live or fixed LGG from day 18 of pregnancy until natural delivery. After genotyping, offspring mice received 10⁷ cfu of live or fixed LGG for 0-5 days after birth.

Results

Early life LGG colonisation significantly promoted intestinal development, inhibited low-gra

SUBMITTER: Liu X 

PROVIDER: S-EPMC9090826 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature