Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.

ABSTRACT:

Background

Group B streptococcus (GBS) colonisation during pregnancy can lead to invasive GBS disease (iGBS) in infants, including meningitis or sepsis, with a high mortality risk. Other outcomes include stillbirths, maternal infections, and prematurity. There are data gaps, notably regarding neurodevelopmental impairment (NDI), especially after iGBS sepsis, which have limited previous global estimates. In this study, we aimed to address this gap using newly available multicountry datasets.

Methods

We collated and meta-analysed summary data, primarily identified in a series of systematic reviews published in 2017 but also from recent studies on NDI and stillbirths, using Bayesian hierarchical models, and estimated the burden for 183 countries in 2020 regarding: maternal GBS

SUBMITTER: Goncalves BP 

PROVIDER: S-EPMC9090904 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature