Pattern differentiation and tuning shift in human sensory cortex underlie long-term threat memory.

ABSTRACT: The amygdala-prefrontal-cortex circuit has long occupied the center of the threat system,¹ but new evidence has rapidly amassed to implicate threat processing outside this canonical circuit.^2-4 Through nonhuman research, the sensory cortex has emerged as a critical substrate for long-term threat memory,^5-9 underpinned by sensory cortical pattern separation/completion^10,11 and tuning shift.^12,13 In humans, research has begun to associate the human sensory cortex with long-term threat memory,^14,15 but the lack of mechanistic insights obscures a direct linkage. Toward that end, we assessed human olfactory threat conditioning and long-term (9 days) threat memory,

SUBMITTER: You Y 

PROVIDER: S-EPMC9090975 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature