PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence.

ABSTRACT:

Background

Identification of novel molecular target(s) is important for designing newer mechanistically driven approaches for the treatment of prostate cancer (PCa), which is one of the main causes of morbidity and mortality in men. In this study, we determined the role of polo-like kinase 4 (PLK4), which regulates centriole duplication and centrosome amplification (CA), in PCa.

Materials and methods

Employing human PCa tissue microarrays, we assessed the prevalence of CA, correlated with Gleason score, and estimated major causes of CA in PCa (cell doubling vs. centriole overduplication) by staining for mother/mature centrioles. We also assessed PLK4 expression and correlated it with CA in human PCa tissues and cell lines. Further, we determined the effects of PLK4 inhibitio

SUBMITTER: Singh CK 

PROVIDER: S-EPMC9090996 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature