Curcumin treats endometriosis in mice by the HIF signaling pathway.

ABSTRACT:

Objective

The aim of this study was to investigate whether curcumin has a therapeutic effect on endometriosis (EM) and to determine the specific mechanism.

Methods

Network pharmacology was used to obtain the core targets of curcumin for the treatment of EM and the specific biologic processes involved. A mouse model of EM was constructed and divided into different groups, as follows: control, negative control, curcumin, and denogestrel. The number, volume, and degree of adhesions of the lesions in each group were measured. The levels of IL-1β, IL-6, and VEGFA in the peritoneal cavity were measured by enzyme-linked immunosorbent assay (ELISA). Western blot and Q-PCR were used to detect HIF-1α and VEGFA proteins and gene expression levels in the lesion tissues.

Results

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SUBMITTER: Ding J 

PROVIDER: S-EPMC9091111 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature