Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study.

ABSTRACT: Major depressive disorder (MDD) is frequently associated with poor response to treatment. Common antidepressants target neurotransmission and neuronal plasticity, which require adequate energy supply. As imaging studies indicate disturbances in central energy metabolism, and caloric restriction improves neuroplasticity and impacts mood and cognition, correction of energy status might increase the effectiveness of antidepressant treatments and reduce the psychopathological symptoms of depression. Metabolic parameters, stress hormones, and brain-derived neurotrophic factor (BDNF) levels were assessed in serum of depressed inpatients (MDD, N = 21) and healthy volunteers (Ctrl, N = 28) before and after a 72 h fasting period during which only water was consumed. Depression severity was assessed

SUBMITTER: Stapel B 

PROVIDER: S-EPMC9091273 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature