TBC1D2 Promotes Ovarian Cancer Metastasis via Inducing E-Cadherin Degradation.

ABSTRACT:

Background

Ovarian cancer (OC) is the most lethal gynecological malignancy worldwide. Increasing evidence indicates that TBC domain family is implicated in various cellular events contributing to initiation and development of different cancers, including OC. However, the role of TBC1D2, a crucial member of TBC domain family, remains unclear in OC.

Methods

IHC and qRT-PCR were employed to determine TBC1D2 expression in OC tissues and cells. In vitro and in vivo assays involving proliferation, migration, invasion were performed to explore the role of TBC1D2 in OC development. The underlying mechanism by which TBC1D2 promotes OC metastasis were elucidated using bioinformatics analysis, western blotting and co-immunoprecipitation.

Results

Upregulation of TBC

SUBMITTER: Tian J 

PROVIDER: S-EPMC9091366 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature