Simultaneous optimization of ultrasonic-assisted extraction of antioxidant and anticoagulation activities of compounds from Leonurus japonicus Houtt. by response surface methodology.

ABSTRACT: Leonurus japonicus Houtt. is a herbaceous annual of the Lamiaceae family with pantropical distribution; it is called motherwort in China. It plays important roles in anticoagulation and antioxidation. This study aimed to explore the optimization of ultrasound-assisted extraction of multiple compounds from motherwort as well as their antioxidant and anticoagulation activities using response surface methodology. Box-Behnken design was employed to optimize three significant influences, namely extraction time, extraction temperature and ethanol concentration. The optimum extraction parameters acquired based on a combination of the yield of the target compounds and their antioxidant and anticoagulation activities were an extraction time of 38.2 min, an extraction temperature of 30.0 °C,

SUBMITTER: Tan YJ 

PROVIDER: S-EPMC9091479 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature