Exploring Key Genes to Construct a Diagnosis Model of Dilated Cardiomyopathy.

ABSTRACT:

Background

Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and systolic dysfunction. The pathogenesis and etiologies of DCM remain elusive. This study aims to identify the key genes to construct a genetic diagnosis model of DCM.

Methods

A total of 257 DCM samples from five independent cohorts were enrolled. The Weighted Gene Co-Expression Network Analysis (WGCNA) was performed to identify the key modules associated with DCM. The latent mechanisms and protein-protein interaction network underlying the key modules were further revealed. Subsequently, we developed and validated a LASSO diagnostic model in five independent cohorts.

Results

Two key modules were identified using WGCNA. Novel mechanisms related to the extracellular, mitochondrial

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9091505 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature