Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD.

ABSTRACT:

Introduction

Limited information is available on renal osteodystrophy (ROD) and vascular calcification (VC) during early chronic kidney disease (CKD). This study was designed to evaluate ROD and VC in 32 patients with CKD stages II to IV.

Methods

Patients underwent dual-energy X-ray absorptiometry (DXA) for assessment of bone mineral density (BMD) and trabecular bone score (TBS), thoracic computed tomography for VC scoring using the Agatston method, and anterior iliac crest bone biopsy for mineralized bone histology, histomorphometry, and Fourier transform infrared spectroscopy (FTIR). Classical and novel bone markers were determined in the blood.

Results

Mean estimated glomerular filtration rate (eGFR) was 44 ± 16 ml/min per 1.73 m². Of the patients, 84% h

SUBMITTER: El-Husseini A 

PROVIDER: S-EPMC9091581 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature