Enantioselective Nozaki-Hiyama-Kishi allylation-lactonization for the syntheses of 3-substituted phthalides.

ABSTRACT: We report the synthesis of bipyridyl ligands and these ligands were applied in the chromium-catalyzed enantioselective Nozaki-Hiyama-Kishi allylation of substituted (2-ethoxycarbonyl)benzaldehydes and subsequently lactonized to synthesize phthalides with an optimal enantioselectivity of 99%. This approach was applied to synthesize (S)-cytosporone E at a 71% yield in three steps.

SUBMITTER: Kumbhar SV 

PROVIDER: S-EPMC9091628 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature