Double-ratiometric fluorescence imaging of H₂Se and O₂˙^- under hypoxia for exploring Na₂SeO₃-induced HepG2 cells' apoptosis.

ABSTRACT: Sodium selenite (Na₂SeO₃), as an anti-tumor drug for inducing tumor cells' apoptosis, has been widely studied under normoxic conditions and has been shown to exhibit oxidative stress process-induced apoptosis. However, since the real tumor environment is hypoxic, the actual mechanism is still unclear. Hence, considering the main metabolite of Na₂SeO₃ in the metabolic process to be hydrogen selenide (H₂Se) and also that it can be converted to superoxide anion (O₂˙^-) instantaneously in the presence of oxygen, a dual-ratiometric fluorescence imaging system for simultaneous monitoring of the changes of H₂Se and O₂˙^- induced by Na₂SeO₃-guided tumor cell apoptosis u

SUBMITTER: Gao X 

PROVIDER: S-EPMC9091642 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature