Association Between the TP53 Polymorphisms and Breast Cancer Risk: An Updated Meta-Analysis.

ABSTRACT: Background: The relationship of TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms with breast cancer (BC) risk has been analyzed in seventeen published meta-analyses. However, the credibility of statistically significant associations was ignored and many new studies have been reported on these themes. Objectives: To explore whether TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms are associated with BC risk and the clinical phenomena. Methods: To comprehensively search the data (through October 25, 2021), we provided a clear search strategy and reviewed the references of published meta-analyses. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used. Results: The current meta-analysis had a larg

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9091657 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature