High Expression of DC-STAMP Gene Predicts Adverse Outcomes in AML.

ABSTRACT: Acute myeloid leukemia (AML) is a genetically heterogeneous hematological malignancy with poor prognosis. We explored the RNA sequence data and clinical information of AML patients from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database to search for the core molecule for prognosis. The DC-STAMP expression was significantly higher in AML patients, which was linked to old age, unfavorable cytogenetic risk, and death (all p < 0.05). Furthermore, it was revealed that high DC-STAMP expression was an independent unfavorable factor for overall survival (OS) by univariate analysis [hazard ratio (HR): 2.683; 95% confidence interval (CI): 1.723-4.178; p < 0.001] and multivariate analysis (HR: 1.733; 95% CI: 1.079-2.781; p = 0.023). The c

SUBMITTER: Liang Q 

PROVIDER: S-EPMC9091727 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature