Calix[n]arene-based immunogens: A new non-proteic strategy for anti-cocaine vaccine.

ABSTRACT:

Introduction

Cocaine use disorder is a significant public health issue without a current specific approved treatment. Among different approaches to this disorder, it is possible to highlight a promising immunologic strategy in which an immunogenic agent may reduce the reinforcing effects of the drug if they are able to yield sufficient specific antibodies capable to bind cocaine and/or its psychoactive metabolites before entering into the brain. Several carriers have been investigated in the anti-cocaine vaccine development; however, they generally present a very complex chemical structure, which potentially hampers the proper assessment of the coupling efficiency between the hapten units and the protein structure.

Objectives

The present study reports the design, synthesis a

SUBMITTER: da Silva Neto L 

PROVIDER: S-EPMC9091763 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature