Effect of local steroids on urethral strictures: A systematic review and meta-analysis.

ABSTRACT:

Purpose

Urethral stricture disease is common and has high associated morbidity and impact on quality-of-life. This systematic review and meta-analysis aims to summarise current evidence on the efficacy of local urethral steroids post-direct vision internal urethrotomy (DVIU) for the treatment of urethral strictures in males.

Materials and methods

A comprehensive search was performed using reputable databases and registries, up to 22 February 2022. Only randomised control trials in which participants were randomised to DVIU plus local urethral steroids versus DVIU only were included. Statistical analyses were performed using a random-effects model. Quality of evidence was rated according to the GRADE approach.

Results

The search identified seven studies in which 365 pa

SUBMITTER: Soliman C 

PROVIDER: S-EPMC9091821 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature