Diagnostic accuracy of prostate-specific antigen below 4 ng/mL as a cutoff for diagnosing prostate cancer in a hospital setting: A systematic review and meta-analysis.

ABSTRACT:

Purpose

A prostate-specific antigen (PSA) cutoff of 4 ng/mL has been widely used for prostate cancer screening in population-based settings. However, the accuracy of PSA below 4 ng/mL as a cutoff for diagnosing prostate cancer in a hospital setting is inconclusive. We systematically reviewed the accuracy of PSA below 4 ng/mL cutoff in a hospital setting.

Materials and methods

We systematically reviewed the literature by searching major databases until March 2020, and a meta-analysis and quality assessment were performed.

Results

A total of 11 studies were included at the completion of the screening process. The meta-analysis showed a sensitivity of 0.92 and a specificity of 0.16 for a PSA cutoff below 4 ng/mL. The area under the hierarchical summary receiver operating

SUBMITTER: Jin Y 

PROVIDER: S-EPMC9091828 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature