Germline pathogenic variants in unselected Korean men with prostate cancer.

ABSTRACT:

Purpose

Prostate cancer is one of the most heritable cancers and prostate cancer with germline mutations is associated with aggressive features and a poor prognosis. We investigated germline variants in unselected Korean men with prostate cancer.

Materials and methods

In this study, we prospectively collected buccal swab DNA from 120 unselected Korean men with prostate cancer, and performed massively parallel sequencing. Identified germline variants were interpreted according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology 2015 guidelines.

Results

Of the 120 patients, 30 had regional or metastatic disease and 10, 34, 25, and 21 patients were categorized as having low, intermediate, high, or very high-risk disease, respectiv

SUBMITTER: So MK 

PROVIDER: S-EPMC9091831 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature