Altered Gut Microbiota in Children With Hyperuricemia.

ABSTRACT:

Background

In adults, gut dysbiosis may contribute to the pathogenesis of gout. However, the characteristics of gut microbiota in children with hyperuricemia (HUA) in the absence of clinical gout have not been explored.

Objective

This present study analyzed the gut microbiota in children with HUA as compared to controls (Con) and explored bacterial associations that may account for differences.

Methods

A total of 80 children were enrolled in this study; they were divided into HUA and Con according to the level of serum uric acid (UA). The composition of gut microbiota was investigated by 16S rRNA high-throughput sequencing.

Results

Principal coordinate analysis revealed that gut microbiota of the HUA group was clustered together and separated partly from the Co

SUBMITTER: Yuan X 

PROVIDER: S-EPMC9091909 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature