Gold nanorod-based multifunctional nanocarrier for synergistic chemo-photothermal therapy in tumors.

ABSTRACT: Synergistic photothermal therapy (PTT) and chemotherapy is an efficient strategy for tumor therapy. However, it is still a challenge to design a smart delivery system able to release a drug at the appropriate time and site of action. Here, we have synthesized photosensitive molecule 7-(double dodecylamine)-4-hydroxymethylcoumarin which was introduced in a nanocarrier GNR@SiO₂-DOX@CouC₁₂-HA (GSDCH) to achieve manually controlled drug release. The specific nanocarrier was fabricated using a GNR core for photothermal therapy, a mesoporous silica shell for drug loading, and the coumarin moiety as a blocking agent and intelligent controlled switch. In addition, cellular uptake of GSDCH by HeLa cells can be achieved effectively with the help of hyaluronic acid (HA). Owing t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9091941 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature