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Cu-catalyzed cross-coupling reactions of vinyl epoxide with organoboron compounds: access to homoallylic alcohols.

ABSTRACT: Copper-catalyzed cross-coupling reactions of vinyl epoxide with arylboronates to obtain aryl-substituted homoallylic alcohols are described. The reaction selectivity was different to that of previously reported vinyl epoxide ring-opening reactions using aryl nucleophiles. The reaction proceeded under mild conditions, affording aryl-substituted homoallylic alcohols with high selectivity and in good to excellent yields. The reaction provides convenient access to aryl-substituted homoallylic alcohols from vinyl epoxide.

SUBMITTER: Lu XY

PROVIDER: S-EPMC9092012 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Cu-catalyzed cross-coupling reactions of vinyl epoxide with organoboron compounds: access to homoallylic alcohols.

Lu Xiao-Yu XY Li Jin-Song JS Wang Jin-Yu JY Wang Shi-Qun SQ Li Yue-Ming YM Zhu Yu-Jing YJ Zhou Ran R Ma Wen-Jing WJ

RSC advances 20181212 72

Copper-catalyzed cross-coupling reactions of vinyl epoxide with arylboronates to obtain aryl-substituted homoallylic alcohols are described. The reaction selectivity was different to that of previously reported vinyl epoxide ring-opening reactions using aryl nucleophiles. The reaction proceeded under mild conditions, affording aryl-substituted homoallylic alcohols with high selectivity and in good to excellent yields. The reaction provides convenient access to aryl-substituted homoallylic alcoho ...[more]

PMID: 35559282

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